The medium tablet contains approximately 325 milligrams of the active ingredient acetylsalicylic acid with an inert binding material such as starch. 1.
When the crystallization process seems complete, pour the mixture into a Buckner funnel. Can you see what effect it had on the end product? Acetic anhydride Aspirin has been used as a medicine by the ancient Greeks and the pharaohs of Egypt. Compare the literature melting point and infrared spectrum to the experimental and comment on the purity of your aspirin. Büchner Funnel (1)
Purify the rest of the aspirin by recrystallization. It is effective in reducing pain (it is an analgesic), reducing inflammation (anti-inflammatory), reducing fever (antipyretic), and thinning blood (anti-coagulant). Our products complement your teaching and help your students engage with key STEM concepts. Why one bond forms and another breaks. What is organic chemistry and why it is important? 01 of 05. * Using the literature, obtain an IR spectrum for aspirin and compare it to the one generated using the FT-IR in your lab. Conc. Answer the following post-lab question: If 0.150 moles of salicylic acid and excess acetic acid are used during a synthesis of aspirin, how many grams of aspirin will be obtained if the reaction gives a 38% yield? This is accomplished by dissolving the acid in warm ethyl alcohol, adding cold water, and then allowing it to recrystallize in an ice bath. Your email address will not be published. Dispose the filtrate it the appropriate waste container. You should see small grain white crystals with obvious recurring units. Collecting Data (Obervations & Measurements): Interpretating Data (Calculations & Reasoning): Presenting your Conclusions (how to prepare your report). These resonance forms will help you understand why a partial positive charge appears on the carbon atom in acetic anhydride and how this results in a new bond forming at that carbon. From that structure we can begin to understand why and how chemical reactions occur.
Calculate the percent yield of your synthesis. Synthesize a sample of acetylsalicylic acid (aspirin). Salicylic acid is extremely bitter tasting, and frequent use can cause severe stomach irritation. How did it affect the end product? This experiment features the following sensors and equipment. How to synthesize aspirin – Acetylsalicylic acid – Introduction and history: Synthesis of aspirin Synthesis of aspirin is listed here briefly Aspirin is the drug the most widely used over the counter. The use of aspirin had its origin in the 18th century, when it … Put the flask in an ice bath to cool the mixture and speed up crystallization. Please consider supporting us by disabling your ad blocker. How has this affected the actual performance of the product? sulfuric acid. Vernier Fluorescence/UV-VIS Spectrophotometer. The ice bath slowed down the molecules, making it easier for them to stick together and “drop” from the solution or crystallize. Stir and warm the beaker to dissolve the crystals.
If you are calculating the actual and theoretical yield , be sure to note how much salicylic acid you actually measured. Vernier products are designed specifically for education and held to high standards. Record the mass to the nearest 0.01 g. 3. 400 mL Beaker (2) Weigh it again. Add about 10 mL of ice-cold deionized water to the flask and cool in an ice bath until crystallization appears to be complete. Synthesis of Aspirin …
16. But opting out of some of these cookies may have an effect on your browsing experience. Rubber Stopper (1) Be careful not to heat the water bath above 85 ˚C. As shown in the above reaction, phosphoric acid, H 3 PO 4 acts as a catalyst in the initial mixture of the reactants in order to speed up the reaction.
Meltemp, Salicylic acid Q2: If 0.150 moles of salicylic acid and excess acetic acid are used during a synthesis of aspirin, how many grams of aspirin will be obtained if the reaction gives a 38% yield? Once crystallization has started, place the beaker in an ice bath to complete the recrystallization. What is microbiology definition and history?
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Find your dealer for local prices. (Show your work). C1 - Calculate the moles of each reagent and determine the limiting reagent for this reaction.
The aspirin is allowed to dry, weighed, and then the percent yield is calculated. Our products support state requirements for NGSS, AP, and more.
Salicylic acid has a group -OH (an alcohol) and a carboxyl group -COOH (an organic acid). A product was dissolved and lost in the washing process. Our workshops and online courses prepare you for science education at all levels. You will determine the percent yield of aspirin and you will confirm it's identity with FT-IR spectroscopic anaylsis. Your two primary objectives in this experiment will be to synthesize and analyze aspirin.
Washing the aspirin removes most of the unreacted salicylic acid and acetic anhydride to give a purer product. The acid part of the molecule is one of the factors that causes stomach irritation. Place the flask in a beaker of hot water for ~ 15 minutes. 12. How has synthesis used different temperatures to affect the solubility of aspirin? Apply suction filtration through the funnel and wash the crystals with a few milliliters of ice water. Section I – Procedure: summarize the procedure using a flow chart format. Acetylsalicylic acid is the chemical name for aspirin, the ubiquitous pain reliever. The aspirin formed will be contaminated with acetic acid and must be purified by recrystallization.
Remove the crystals to dry the paper to remove excess water. Additional equipment may be required. Weigh accurately 3.00 grams of salicylic acid and transfer to a dry Erlenmeyer flask. There is more than one way to synthesize aspirin; in this experiment, you will react acetic anhydride with salicylic acid in the presence of phosphoric acid (which acts as a catalyst). Weigh a piece of filter paper and vacuum filter the product. Hydrogen is a gas and first element on periodic table? Synthesis of aspirin is listed here briefly Aspirin is the drug the most widely used over the counter. Add 6 ml of acetic anhydride and 5-8 drops of 85% phosphoric acid to the flask.
125 mL Erlenmeyer Flask (1) It let's us know not just the composition of reactants and products but their structure as well. 5. Can you predict how these groups affect the properties of the molecule and how the body reacts? Section VI – Post-lab: Give a source of error in this experiment. Figure 1.1 Aspirin synthesis: chemical reaction involving salicylic acid and acetic anhydride as reactants and aspirin and acetic acid as products. Stir to dissolve it completely, and then add 5 mL of warm (70°C) deionized water. Can you identify the functional groups in salicylic acid? In this reaction, the –OH on the salicylic acid acts as the alcohol and the acetic anhydride acts like a carboxylic acid. Explore the options. One of the compounds used in the synthesis of aspirin is salicylic acid, which is itself a pain reliever that was known to many ancient cultures, including the Native Americans who extracted it from willow tree bark. 7. Originally, aspirin was obtained by boiling the bark of the white willow. This lab involves strong acids.
Q1: Give a source of error in this experiment. Determine the melting point of your aspirin sample (Your instructor will demonstrate how to use the melt-temp apparatus. Save my name, email, and website in this browser for the next time I comment. 8.
14. Rinse the residue on the filter paper with 2 mL of ice-cold deionized water. Find ready-to-use experiments that help you integrate data collection technology into your curriculum. The -OH group of salicylic acid combined with acetic acid, producing water and an ester group. Required fields are marked *. Phosphoric or sulfuric acid and acetic anhydride can cause severe burns.
Find creative lab ideas using Vernier sensors. Add a drop of 1% iron chloride III to separate the test tubes containing a few crystals of each substance. Be sure to use a water bath that is large enough for any bubbles which form in the water to easily pass around the Erlenmeyer flask you are heating. Determine the mass of the aspirin. In the fume hood, add five drops of concentrated acid to the flask containing the salicylic acid and acetic anhydride and swirl to mix everything thoroughly. Experiment 8 – Synthesis of Aspirin Aspirin is an effective analgesic (pain reliever), antipyretic (fever reducer) and anti-inflammatory agent and is one of the most widely used non-prescription drugs. The chemical name for aspirin is acetylsalicylic acid. Filtration Flask (1) If crystals do not appear scratch the walls of the flask with a stirring rod to induce crystallization.
Be aware that using too much water or warm water in this step may affect your results. Gas building in a sealed container is the primary cause of laboratory explosions and heating the beaker to high or not providing sufficient space around the Erlenmeyer flask may produce an explosion.