It … Sucralose is made from sugar but contains no calories and is … Want to turn your favorite dessert recipe into a less added sugar version? Sucralose is an artificial sweetener. Splenda, on the other hand, is a low-calorie artificial sweetener. While that package of Equal, Sweet‘N Low, or Splenda (yes, even Splenda !) Splenda is the most popular product made from it. Simply select the type of Splenda Product you want to use from the menu below, then the amount of sugar … Conversion Chart. So, unlike sugar, which is derived from natural resources, Splenda is made in the lab and processing plants.